Additional projects

SCAHT is also involved in other defined areas of research including the following collaborative projects:

​For details on the projects see descriptions below.


Dermal penetration and metabolism of Bisphenol A (BPA)

Project Lead 

  • Dr. Nancy Hopf, IST - Institut universitaire romand de Santé au Travail

Partners 

  • Federal Office of Public Health (FOPH)

Rationale for project

Bisphenol A (BPA, CAS No. 80-05-7) is a plastic monomer and plasticizer, primarily used in the production of polycarbonate plastics, epoxy resins, and in carbonless paper. It is one of the world’s highest production-volume chemicals, with more than 2 million metric tons produced worldwide in 2003. In the general population, skin contact may contribute to the overall exposure of humans to BPA when touching store receipts (thermal paper).

Objectives

The first objective is to assess the skin permeability of BPA in exposure conditions close to real-life situations.  Percutaneous permeation of BPA and its metabolites through viable human skin will be measured using flow-through diffusion cells. The second objective is to assess the permeation of current and future BPA substitutes. The percutaneous permeation of Pergafast 201, bisphenol S or bisphenol F will be investigated using the same method as for BPA.

For further information contact

Dr. Nancy Hopf
nancy.hopf@hospvd.ch

Elena Reale
elena.reale@chuv.ch
 


Toward a better use of regulatory exposure models including national and non-national occupational data

Project Lead 

  • David Vernez, IST - Institut universitaire romand de Santé au Travail

Partners 

  • Swiss State Secretariat for Economic Affairs (SECO)
  • BAuA (D)
  • INRS (F)
  • NIOSH (US)
  • KIST (D)
  • TNO (NL)

Rationale for project

A variety of models for occupational exposure estimation has been developed under the REACH Regulation (Registration, Evaluation, Authorization and restriction of Chemicals) for the evaluation of chemicals prior to their marketing. The models vary in structure, applicability domains, required level of user expertise and output estimations. Moreover, their performance has been tested only against limited data. These models therefore contain a certain amount of uncertainty.

Objectives

The goal of this project is focused on the improvement of the accuracy and the use of these models, primarily the three most sophisticated, i.e. Advanced REACH Tool, Stoffenmanager, and ECETOC TRA. This includes application of advanced statistical analyses such as Bayesian inference, and the web-development of a user-friendly platform. By combining different measured and modeled values, the accuracy of the exposure predictions is expected to increase. By using more comprehensive and curated data entry methods, uncertainty from this source should be minimized.

For further information contact

Nenad Savic
nenad.savic@chuv.ch
 


European Drug Emergency Network (Euro-DEN) collecting data on recreational drug use

Project Lead

  • Matthias Liechti, Universitätshospital Basel

Partners

  • P. Dargan, King’s College London (UK)
  • K. E. Hovda, Oslo University Hospital (N)
  • European Monitoring Centre for Drugs and Drug Addiction, Lisbon (P)
  • B. Megarbane, Lariboisière Hospital, Paris (F)
  • Other network members

Rationale for project

The goal of the project is to collect data on recreational drug toxicity in medical emergency departments across Europe. Basel acts as the Swiss center in the EU Euro-DEN project which includes 15 other centers. The objective is to develop and maintain a network of sentinel centers with a specialist clinical and research interest in the adverse consequences of recreational drugs and in particular of new psychoactive substances.

Objectives

Systematic collection of data on adverse consequences of recreational drugs in emergency room admissions, to identify, monitor and respond to new use and adverse outcome patterns. The Basel center also studies the pharmacology and toxicology of novel psychoactive substances in vitro.

For further information contact

Prof. Matthias Liechti
matthias.liechti@usb.ch