10 May 2021 - 10 May 2021

OECD webinar: 'Gaining acceptance in next generation PBK modelling approaches for regulatory assessments'

OECD webinar for model developers and regulators, 10 May 2021, 13:20 - 15:30 CEST

The OECD is increasingly exploring the use of alternative (non-animal) methods to aid the chemical risk assessment process. Recently, the OECD published a Guidance Document on the Characterisation, Validation And Reporting of Physiologically Based Kinetic (PBK) Models For Regulatory Purposes.

This guidance aims to increase the confidence in the use of PBK models parameterised with data derived from in vitro and in silico methods, and help address “unfamiliar” uncertainties associated with these methods. 

Join the webinar to hear about the assessment framework for PBK models that was developed to evaluate the attributes and uncertainties of these models, including a dedicated discussion on sensitivity analysis. This webinar will present the scientific workflow for characterising and validating PBK models together with a template for documenting PBK models in a systematic manner and a checklist to support model evaluation.




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