Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

Nunes C, Proença S, Ambrosini G, Pamies D, Thomas A, Kramer NI, Zurich MG

Frontiers in Pharmacology,  6 Sep 2023

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Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Jäger MC, Joos FL, Winter DV, Odermatt A

Current Research in Toxicology,  14 Aoû 2023

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Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase [online ahead of print]

Jäger MC, Kędzierski J, Gell V, Wey T, Kollár J, Winter DV, Schuster D, Smieško M, Odermatt A

Toxicology and Applied Pharmacology,  26 Jul 2023

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The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm

Wehrli L, Galdadas I, Voirol L, Smiesko M, Cambet Y, Jaquet V, Guerrier S, Gervasio FL, Nef S, Rahban R

Frontiers in Cell and Developmental Biology,  20 Jul 2023

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Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation [online ahead of print]

Kędzierski J , Allard JA, Odermatt A, Smieško M

Toxicology Letters,  13 Jul 2023

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Evaluating the food safety and risk assessment evidence-base of polyethylene terephthalate oligomers: A systematic evidence map

Schreier VN, Çörek E, Appenzeller-Herzog C, Brüschweiler BJ, Geueke B, Wilks MF, Schilter B, Muncke J, Simat TJ, Smieško M, Roth N, Odermatt A

Environment International,  30 Jui 2023

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Extended steroid profiling in H295R cells provides deeper insight into chemical-induced disturbances of steroidogenesis: Exemplified by prochloraz and anabolic steroids

Jäger MC, Patt M, González-Ruiz V, Boccard J, Wey T, Winter DV, Rudaz S, Odermatt A

Molecular and Cellular Endocrinology,  15 Jui 2023

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Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid

Olesti E, Boccard J, Rahban R, Girel S, Moskaleva NE, Zufferey F, Rossier MF, Nef S, Rudaz S, González-Ruiz V

Metabolomics,  5 Jui 2023

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Zebrafish Larvae as an in vivo Model for Antimicrobial Activity Tests against Intracellular Salmonella

Hauswirth P, Buck J, Puligilla R, Alter CL, Sieber S, Claudi B, Fanous J, Bumann D, Huwyler J

Frontiers in Bioscience,  25 Mai 2023

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Investigation of several chromatographic approaches for untargeted profiling of central carbon metabolism

Girel S, Guillarme D, Fekete S, Rudaz S, González-Ruiz V

Journal of Chromatography,  24 Mai 2023