Novel Strategy to Assess the Neurotoxicity of Organic Solvents Such as Glycol Ethers: Protocol for Combining In Vitro and In Silico Methods With Human-Controlled Exposure Experiments

Hopf NB, Suter-Dick L, Huwyler J, Borgatta M, Hegg L, Pamies D, Paschoud H, Puligilla RD, Reale E, Werner S, Zurich MG

JMIR Research Protocols,  18 Jan 2024

Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems

Parvatam S, Pamies D, Pistollato F, Beken S, Mariappan I, Roth A, Piergiovanni M, Maisonneuve BGC, Ewart L, Majumder A, Dandekar P, Date R, Mahadik K, Thiyagarajan S, Coecke S

Stem Cell Reports,  9 Jan 2024

Repeated Human Exposure to Semivolatile Organic Compounds by Inhalation: Novel Protocol for a Nonrandomized Study

Reale E, Hopf NB, Breider F, Grandjean D, Pirard C, Charlier C, Koch HM, Berthet A, Suarez G, Borgatta M

JMIR Research Protocols,  10 Oct 2023

Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase [online ahead of print]

Jäger MC, Kędzierski J, Gell V, Wey T, Kollár J, Winter DV, Schuster D, Smieško M, Odermatt A

Toxicology and Applied Pharmacology,  15 Sep 2023

Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

Nunes C, Proença S, Ambrosini G, Pamies D, Thomas A, Kramer NI, Zurich MG

Frontiers in Pharmacology,  6 Sep 2023

Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies

Svendsen C, Whaley P, Vist GE, Husøy, Beronius A, Di Consiglio E, Druwe I, Hartung T, Hatzi VI, Hoffmann S, Hooijmans CR, Machera K, Robinson JF, Roggen E, Rooney AA, Roth N, Spilioti E, Spyropoulou A, Tcheremenskaia O, Testai E, Vinken M, Mathisen GH

Evidence-Based Toxicology,  31 Aoû 2023

Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Jäger MC, Joos FL, Winter DV, Odermatt A

Current Research in Toxicology,  14 Aoû 2023

Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation

Kędzierski J , Allard JA, Odermatt A, Smieško M

Toxicology Letters,  1 Aoû 2023

The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm

Wehrli L, Galdadas I, Voirol L, Smiesko M, Cambet Y, Jaquet V, Guerrier S, Gervasio FL, Nef S, Rahban R

Frontiers in Cell and Developmental Biology,  20 Jul 2023

Evaluating the food safety and risk assessment evidence-base of polyethylene terephthalate oligomers: A systematic evidence map

Schreier VN, Çörek E, Appenzeller-Herzog C, Brüschweiler BJ, Geueke B, Wilks MF, Schilter B, Muncke J, Simat TJ, Smieško M, Roth N, Odermatt A

Environment International,  30 Jui 2023