Publications All Publications

Presentations to the emergency department with non-medical use of benzodiazepines and Z-drugs: profiling and relation to sales data

Lyphout C
Yates C
Margolin ZR
Dargan PI
Dines AM
Heyerdahl F
Hovda KE
Giraudon I
Bucher-Bartelson B
Green JL
Euro-DEN Research Group
Wood DM
European Journal of Clinical Pharmacology
31/01/2019

Authors' response to the letter to the editor by Jowsey et al. [Epub ahead of print]

Sanvido O
Schmid K
Bormann P
Regulatory Toxicology and Pharmacology
03/01/2019

Steroid profiles in both blood serum and seminal plasma are not correlated and do not reflect sperm quality: Study on the male reproductive health of fifty young Swiss men

Clinical Biochemistry
31/12/2018

Optimizing drug discovery by Investigative Toxicology: Current and future trends [Epub ahead of print]

Beilmann M
Boonen H
Czich A
Dear G
Hewitt P
Mow T
Newham P
Oinonen T
Pognan F
Roth A
Valentin JP
Van Goethem F
Weaver RJ
Birk B
Boyer S
Caloni F
Chen AE
Corvi R
Cronin MTD
Daneshian M
Ewart LC
Hamilton GA
Hartung T
Kangas JD
Kramer NI
Leist M
Marx U
Polak S
Rovida C
Testai E
Van der Water B
Vulto P
Steger-Hartmann T
ALTEX
20/12/2018

Profiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry

Journal of Neuroinflammation
30/11/2018

Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice

Paech F
Abegg VF
Duthaler U
Toxicology
01/11/2018

Longitudinal investigation of the metabolome of 3D aggregating brain cell cultures at different maturation stages by 1H HR-MAS NMR

Diserens G
Vermathen M
Vermathen P
Analytical and Bioanalytical Chemistry
31/10/2018

Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites

Marsousi N
Daali Y
Fontana P
Reny JL
Ancrenaz-Sirot V
Calmy A
Desmeules JA
Samer CF
Clinical Pharmacokinetics
31/10/2018

A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models

Sanvido O
Schmid K
Bormann P
Regulatory Toxicology and Pharmacology
31/10/2018

Preclinical hazard evaluation strategy for nanomedicines [Epub ahead of print]

Siegrist S
Cörek E
Detampel P
Wick P
Nanotoxicology
05/09/2018

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation [Epub ahead of print]

Mech A
Rasmussen K
Jantunen P
Alessandrelli M
Bernauer U
Bleeker EAJ
Bouillard J
Di Prospero Fanghella P
Draisci R
Dusinska M
Encheva G
Flament G
Haase A
Handzhiyski Y
Herzberg F
Jacobsen NR
Jeliazkov V
Jeliazkova N
Nymark P
Grafström R
Oomen AG
Polci ML
Riebeling C
Shivachev B
Stateva S
Tanasescu S
Tsekovska R
Wallin H
Zellmer S
Apostolova MD
Nanotoxicology
05/09/2018

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Fritsche E
Grandjean P
Crofton KM
Aschner M
Goldberg A
Heinonen T
Hessel EVS
Hogberg HT
Bennekou SH
Lein PJ
Leist M
Mundy WR
Paparella M
Piersma AH
Sachana M
Schmuck G
Solecki R
Terron A
Monnet-Tschudi F
Witters H
Bal-Price A
Toxicology and Applied Pharmacology
01/09/2018

Effect of the catechol-O-methyltransferase inhibitors tolcapone and entacapone on fatty acid metabolism in HepaRG cells

Felser A
Duthaler U
Toxicological Sciences
01/08/2018

High-dose immunosuppression to prevent death after paraquat self-poisoning - a randomised controlled trial

Gawarammana I
Buckley NA
Mohamed F
Naser K
Jeganathan K
Ariyananada PL
Wunnapuk K
Dobbins TA
Tomenson JA
Eddleston M
Dawson AH
Clinical Toxicology (Phila)
31/07/2018

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Berger B
Bachmann F
Duthaler U
Haschke M
Frontiers in Pharmacology
24/07/2018

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Bal-Price A
Hogberg HT
Crofton KM
Daneshian M
Fritsche E
Heinonen T
Hougaard Bennekou S
Klima S
Piersma AH
Sachana M
Shafer TJ
Terron A
Monnet-Tschudi F
Viviani B
Waldmann T
Westerink RHS
Witters H
Zurich MG
Leist M
ALTEX
09/07/2018

Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways

Villeneuve DL
Landesmann B
Allavena P
Ashley N
Bal-Price A
Corsini E
Halappanavar S
Hussell T
Laskin D
Lawrence T
Nikolic-Paterson D
Pallardy M
Paini A
Pieters R
Roth R
Tschudi-Monnet F
Toxicological Sciences
01/06/2018

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells

Frontiers in Pharmacology
23/04/2018

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines

Mingard C
Paech F
Journal of Applied Toxicology
31/03/2018

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis

Engeli RT
Fürstenberger C
Heliyon
28/02/2018

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells

Paech F
Mingard C
Abegg VF
Toxicology
15/02/2018

Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software

Marsousi N
Desmeules JA
Daali Y
Biopharmaceutics & Drug Disposition
31/01/2018

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Terron A
Bal-Price A
Paini A
Monnet-Tschudi F
Bennekou SH
EFSA WG EPI1 Members
Leist M
Schildknecht S
Archives of Toxicology
31/01/2018

Navigating in vitro bioactivity data: investigating available resources using model compounds

Ilmjarv S
Augsburger F
Tjalling Bolleman J
Liechti R
Bridge A
Jaquet V
Xenarios I
Krause KH
bioRxiv
17/01/2018

Contrast-induced nephropathy: Basic concepts, pathophysiological implications and prevention strategies

Mamoulakis C
Tsarouhas K
Fragkiadoulaki I
Heretis I
Spandidos DA
Tsitsimpikou C
Tsatsakis A
Pharmacology & Therapeutics
31/12/2017

Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study

Randazzo GM
Tonoli D
Strajhar P
Xenarios I
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
15/12/2017

ART, Stoffenmanager, and TRA: A Systematic Comparison of Exposure Estimates Using the TREXMO Translation System

Gasic B
Annals of Work Exposures and Health
15/12/2017

Unravelling the effects of multiple experimental factors in metabolomics, analysis of human neural cells with hydrophilic interaction liquid chromatography hyphenated to high resolution mass spectrometry

Journal of Chromatography. A.
08/12/2017

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Paech F
Messner S
Spickermann J
Wind M
Schmitt-Hoffmann AH
Witschi AT
Howell BA
Church RJ
Woodhead J
Engelhardt M
Maurer M
Archives of Toxicology
30/11/2017

PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity

Kiene K
Schenk SH
Porta F
Ernst A
Witzigmann D
Grossen P
European Journal of Pharmaceutics and Biopharmaceutics
31/10/2017