An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat

Nunes C, Singh P, Mazidi Z, Murphy C, Bourguignon A, Wellens S, Chandrasekaran V, Ghosh S, Zana M, Pamies D, Thomas A, Verfaillie C, Culot M, Dinnyes A, Hardy B, Wilmes A, Jennings P, Grillari R, Grillari J, Zurich MG, Exner T.

Toxicology in Vitro,  30 Jun 2022

Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network

Spinu N, Cronin MTD, Lao J, Bal-Price A, Campia I, Enoch, SJ, Madden JC, Lagares LM, Novic M, Pamies D, Scholz S, Villeneuve DL, Worth AP

Computational Toxicology,  28 Feb 2022

Towards a qAOP framework for predictive toxicology - Linking data to decisions

Paini A, Campia I, Cronin MTD, Asturiol D, Ceriani L, Exner TE, Gao W, Gomes C, Kruisselbrink J, Marvin Martens M, Meek MEB, Pamies D, Pletz J, Scholz S, Schüttler A, Spînu N, Villeneuve DL, Clemens Wittwehr C, Worth A, Luijten M

Computational Toxicology,  28 Feb 2022

Human IPSC-Derived Model to Study Myelin Disruption

Chesnut M, Paschoud H, Repond C, Smirnova L, Hartung T, Zurich MG, Hogberg HT, Pamies D

International Journal of Molecular Sciences,  31 Aug 2021

Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity

Chesnut M, Hartung T, Hogberg H, Pamies D

International Journal of Molecular Sciences,  25 Jul 2021

Neuroinflammatory Response to TNFα and IL1β Cytokines Is Accompanied by an Increase in Glycolysis in Human Astrocytes In Vitro

Pamies D, Sartori C, Schvartz D, González-Ruiz V, Pellerin L, Nunes C, Tavel D, Maillard V, Boccard J, Rudaz S, Sanchez JC, Zurich MG

International Journal of Molecular Sciences,  14 Apr 2021

Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model

Yan L , Messner CJ, Zhang X, Suter-Dick L

Environmental Research,  31 Mar 2021