Publications
Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells
Paech F, Mingard C, Grünig D, Abegg VF, Bouitbir J, Krähenbühl S
Toxicology, 15 Feb 2018
Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software
Marsousi N, Desmeules JA, Rudaz S, Daali Y
Biopharmaceutics & Drug Disposition, 31 Jan 2018
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, EFSA WG EPI1 Members, Leist M, Schildknecht S
Archives of Toxicology, 31 Jan 2018
Navigating in vitro bioactivity data: investigating available resources using model compounds
Ilmjarv S, Augsburger F, Tjalling Bolleman J, Liechti R, Bridge A, Sandström J, Jaquet V, Xenarios I, Krause KH
bioRxiv, 17 Jan 2018
Contrast-induced nephropathy: Basic concepts, pathophysiological implications and prevention strategies
Mamoulakis C, Tsarouhas K, Fragkiadoulaki I, Heretis I, Wilks MF, Spandidos DA, Tsitsimpikou C, Tsatsakis A
Pharmacology & Therapeutics, 31 Dec 2017
Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study
Randazzo GM, Tonoli D, Strajhar P, Xenarios I, Odermatt A, Boccard J, Rudaz S
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 15 Dec 2017
ART, Stoffenmanager, and TRA: A Systematic Comparison of Exposure Estimates Using the TREXMO Translation System
Savic N, Gasic B, Vernez D
Annals of Work Exposures and Health, 15 Dec 2017
Unravelling the effects of multiple experimental factors in metabolomics, analysis of human neural cells with hydrophilic interaction liquid chromatography hyphenated to high resolution mass spectrometry
González-Ruiz V, Pezzatti J, Roux A, Stoppini L, Boccard J, Rudaz S
Journal of Chromatography. A., 8 Dec 2017
Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072
Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, Krähenbühl S, Maurer M
Archives of Toxicology, 30 Nov 2017
PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity
Kiene K, Schenk SH, Porta F, Ernst A, Witzigmann D, Grossen P, Huwyler J
European Journal of Pharmaceutics and Biopharmaceutics, 31 Oct 2017