SCAHT Directorate

Currently, there is a paradigm shift in regulatory toxicology, moving from animal testing to the development and implementation of human-relevant, mechanistic and non-animal testing. An area of particularly high animal utilisation is Developmental and Reproductive Toxicity (DART) and new methodologies, such as human stem cell-derived in vitro models, hold promise for more efficient and protective DART testing. The International STakeholder NETwork (ISTNET) aims at creating a DART testing roadmap for regulatory purposes through effective communication and discussion among actors from academia, regulation and industry.

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The European Partnership for the Assessment of Risks from Chemicals (PARC) is seeking to develop next-generation chemical risk assessment, incorporating both human health and the environment in a "One Health“ approach. SCAHT is participating in Work Package 6, "Innovation in Regulatory Risk Assessment," with two sub-projects: READY-AI and NAM4NT.

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For more information on the project READY-AI click here

For more information on the project NAM4NT click here

The CHIASMA Project is a major Horizon Europe research initiative focused on transforming how the safety and sustainability of chemicals and advanced materials are assessed. It develops and integrates a comprehensive set of New Approach Methodologies (NAMs) into a robust, user-friendly framework for regulatory human and environmental safety evaluation.

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The ONTOX Project is a collaborative Horizon Europe research initiative aiming at transforming chemical safety assessment by building an ontology-based framework rooted in human data, innovative methods (NAMs), adverse outcome pathways and probabilistic risk assessment. The project seeks to improve how chemical risks are identified and characterised, address emerging health concerns, and provide tools and strategies that enhance regulatory decision-making across jurisdictions.

For more information on the project, click here