Global Policy Updates
Regions
- OECD – New Approach Methodologies (NAMs): OECD activities supporting international harmonisation and regulatory acceptance of NAMs.
- OECD Guidance on Grouping of Chemicals and Alternative Approaches: OECD guidance document incorporating alternatives to animal testing in chemical assessment.
- ICH M15 Guideline – General Principles for Model-Informed Drug Development: Newly adopted ICH guideline establishing a harmonised framework for model-informed drug development (MIDD), strengthening global regulatory acceptance of computational and mechanistic approaches in pharmaceutical development.
- EMA – ICH M15 Scientific Guideline: European Medicines Agency overview of the ICH M15 guideline and its role in integrating modelling and simulation into regulatory decision-making.
- Swiss 3R Competence Centre (Swiss 3RCC): Switzerland’s national competence centre dedicated to the replacement, reduction, and refinement (3Rs) of animal experimentation, supporting NAM development through funding, education, and policy activities.
- Swiss Federal Food Safety and Veterinary Office – 3Rs Principles: Official Swiss policy framework stating that animal experiments must be replaced by alternative methods whenever possible.
- 3Rs in Swiss Law – University of Zurich Overview of how the 3Rs principles are embedded as legally binding requirements within Swiss law.
- Swiss National Science Foundation – Animals in ResearchSNSF statement on implementation of the 3Rs principles in Swiss research funding and scientific practice.
- FDA Draft Guidance on Alternatives to Animal Testing in Drug Development (2026)
- FDA draft guidance supporting the use of NAMs and human-relevant methods in regulatory submissions.
- FDA Modernization Act 2.0 Overview Landmark U.S. legislation removing the blanket requirement for animal testing in drug development.
- European Commission Roadmap Towards Phasing Out Animal Testing: EU roadmap supporting the transition toward non-animal approaches in chemical safety assessment.
- EU Cosmetics Animal Testing Ban: Overview of the EU’s cosmetics testing and marketing bans on animal-tested cosmetic products and ingredients.
- EPAA – European Partnership for Alternative Approaches to Animal Testing: European Commission platform promoting replacement, reduction, and refinement (3Rs) approaches.
- UK Parliament POSTnote: Technology Alternatives to Animals in Life Sciences Research (2026)Overview of UK policy developments and emerging human-relevant technologies replacing animal models.
- UK Government Strategy to Replace Animals in Science UK strategy supporting reduction and replacement of animal use in scientific research.