Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Berger B, Bachmann F, Duthaler U, Krähenbühl S, Haschke M

Frontiers in Pharmacology,  24 Jul 2018

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M

ALTEX,  9 Jul 2018

Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways

Villeneuve DL, Landesmann B, Allavena P, Ashley N, Bal-Price A, Corsini E, Halappanavar S, Hussell T, Laskin D, Lawrence T, Nikolic-Paterson D, Pallardy M, Paini A, Pieters R, Roth R, Tschudi-Monnet F

Toxicological Sciences,  1 Jun 2018

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells

Grünig D, Duthaler U, Krähenbühl S

Frontiers in Pharmacology,  23 Apr 2018

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines

Mingard C, Paech F, Bouitbir J, Krähenbühl S

Journal of Applied Toxicology,  31 Mar 2018

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis

Engeli RT, Fürstenberger C, Kratschmar DV, Odermatt A

Heliyon,  28 Feb 2018

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells

Paech F, Mingard C, Grünig D, Abegg VF, Bouitbir J, Krähenbühl S

Toxicology,  15 Feb 2018

Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software

Marsousi N, Desmeules JA, Rudaz S, Daali Y

Biopharmaceutics & Drug Disposition,  31 Jan 2018

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, EFSA WG EPI1 Members, Leist M, Schildknecht S

Archives of Toxicology,  31 Jan 2018

Navigating in vitro bioactivity data: investigating available resources using model compounds

Ilmjarv S, Augsburger F, Tjalling Bolleman J, Liechti R, Bridge A, Sandström J, Jaquet V, Xenarios I, Krause KH

bioRxiv,  17 Jan 2018